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Tuesday, October 22, 2013

Synthetic Chemistry as a Window into Biology: Probing Active Site Metal–Oxo and Metal–Hydroxo Complexes

Inorganic Inorganic Seminar
1640 Chemistry
4:00 PM - 5:30 PM
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Speaker:   Andrew Borovik, University of California, Irvine
Abstract:   Active sites of proteins containing metal–oxo and hydroxo units have important consequences in metallobiochemistry. In many cases, they have been proposed to be key intermediates during catalysis, especially in proteins that utilized dioxygen for oxidative transformation. In addition, it has been proposed that intermediates formed during water oxidation at the oxygen-evolving complex within Photosystem II contain both metal–oxo and metal–hydroxo units. Developing synthetic systems having similar units has been challenging because of difficulties in replicating the structural components associated with active sites in metalloproteins. We have been developing synthetic systems to duplicate some of the structural features found in proteins, including those found within the secondary coordination sphere (e.g., hydrogen bonding networks). This talk will describe our latest efforts in preparing and characterizing new metal-oxo and hydroxo complexes with a variety of biological relevant metal ions. Included in the discussion will be methods to prepared heterometallic complexes containing hydroxo and oxo ligands.