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Friday, October 18, 2013

The Foundation of Molecular Medicine: A Chemical Biology Approach

Philip J. Elving Analytical Lecture
1640 Chemistry
4:00 pm - 5:30pm
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Speaker:   Weihong Tan , The University of Florida
Abstract:   A full understanding of the molecular basis of diseases depends on the development of molecular probes able to recognize disease targets of interest. Until very recently, such tools have been absent from the clinical practice of medicine. One of the newest molecular probes, and also one that holds most promise, is a new class of designer nucleic acids, termed aptamers, which are single-stranded DNA/RNA able to recognize specific targets, such as single proteins and even small molecules. Recently, we applied a simple, fast and reproducible cell-based aptamer selection strategy called Cell-SELEX which uses whole, intact cells as the target for aptamer selection. This selection process then generates multiple aptamers for the specific recognition of biological cells, but without the need for prior knowledge about the signature of target cell-surface molecules. The selected aptamers have dissociation constants in the nanomolar to picomolar range. Thus far, we have selected aptamer probes for many different diseases, and used them to carry out studies at the vanguard of biomedical science, including ultrasensitive detection of tumors, molecular imaging, targeted drug delivery, and, most critically, cancer biomarker discovery. Taken together, these molecular level tools form a solid scientific platform from which to pursue advanced studies in molecular medicine. We will report our most recent progress in this exciting research area, especially the molecular elucidation of cancer biomarkers and targeted drug development.