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Tuesday, March 18, 2014

Towards a Green Macrocyclization Protocol: Development of Novel Strategies and Catalysis

Organic Chemistry Organic Seminar
1640 Chemistry
4:00 PM - 5:30 PM

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Speaker:   Shawn Collins, University of Montreal
Abstract:   Our group has been developing novel techniques for the synthesis of macrocycles. Novel conformational control elements have been demonstrated to access rigid, chiral, well-defined macrocycles and cyclophanes. More recently, we have made progress towards developing general approaches for controlling dilution effects in macrocyclization via a “phase separation” strategy. The “phase separation” strategy has been applied to important contemporary chemical transformations commonly used to construct macrocycles, such as olefin metathesis, Glaser-Hay couplings and “Click” cycloadditions. Efforts to develop new catalytic strategies to access macrocycles via direct macrolactonization or Sonogashira cross-coupling will also be presented.