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Friday, May 02, 2014

New Heterocyclic Chemistry of Alkyl Azides: From Methods to Libraries to Hits

Bristol-Meyers Squibb in Organic Synthesis Organic Lecture
1640 Chemistry
4:00 PM - 5:15 PM

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Speaker:   Jeffrey Aube, The University of Kansas
Abstract:   A primary goal of chemical biology is to provide new chemical matter for screening and other biological applications. One way to accomplish this is to develop new synthetic methods that provide attractive routes to small molecules. Our laboratory has a long-standing interest in developing new reactions, notably those involving alkyl azides. In this seminar, I will describe how we pursue synthetic methodology work and apply it to the construction of compound libraries. Our interest also extends to applying synthesis for the development of biological probes and drug leads in neuroscience; an example of our work in this area will be provided.