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Monday, February 27, 2017


Seminar

Development of Students' Chemical Thinking


Prof. Hannah Sevian , Associate Professor, University of Massachusetts, Boston
Development of Students' Chemical Thinking
CHEM 1640
4:00 PM - 5:00 PM


Wednesday, March 08, 2017


Seminar

Characterizing Protein Glutathionylation in Response to Mitochondrial ROS


Prof Young-Hoon Ahn , Assistant Professor, Wayne State University
Characterizing Protein Glutathionylation in Response to Mitochondrial ROS
Mitochondria are the central organelle for cellular metabolism while being an important source of ROS production.1 Importantly, mitochondrial ROS (mROS) are emerging as key pathophysiological molecules in cardiac cells as well as a broad cardiovascular system. The complex role of mROS is largely mediated by protein oxidative modifications, including glutathionylation that is a disulfide bond formation of protein cysteine residue with intracellular glutathione. Although several biochemical methods for identifying glutathionylation are available, individual approach has its own limitations. In order to identify and characterize protein glutathionylation, we recently developed a novel chemical method, namely clickable glutathione, that selectively detects glutathionylation in response to ROS. The central idea was to tag a ‘clickable’ functionality to glutathione by engineering glutathione synthetase (GS), a non-rate limiting enzyme in glutathione (γGlu-Cys-Gly) biosynthesis. With this approach, we analyzed glutathionylation of global and individual proteins in response to metabolic alteration that increases mROS production. Proteomic and biochemical analysis with our clickable glutathione approach led to identifying multiple target proteins of glutathionylation, including SMYD2 implicated in cardiac and skeletal muscle. In this talk, I will present our clickable glutathione approach, characterization of glutathionylation in metabolic alteration, and functional significance of SMYD2 glutathionylation in muscle.
CHEM 1706
4:00 PM - 5:15 PM
brentrm@umich.edu


Thursday, March 09, 2017


Seminar

Applications of Innovative Synthesis in Medicinal Science


Joseph Tucker , Pfizer and Scott Bagley
4:00pm - 5:30pm


Wednesday, March 15, 2017


Willard Lecture Seminar

Heterogeneous Chemistry in the Lower Atmosphere: From Pesticides to Particles


Prof. Barbara Finlayson-Pitts , Distinguished Professor of Chemistry, University of California, Irvine
Heterogeneous Chemistry in the Lower Atmosphere: From Pesticides to Particles
Chem 1640
4:00 PM - 5:30 PM
prattka@umich.edu


Friday, March 24, 2017


Seminar

Professor William Pomerantz, Chembio Seminar


William Pomerantz , University of Minnesota
4 pm - 5:30 pm
amapp@umich.edu


Wednesday, March 29, 2017


Seminar

TBA


Prof. Regan Thomson , Northwestern University
4:00pm - 5:30pm


Thursday, April 06, 2017


Seminar

TBA


Prof. Aaron Aponick , Associate Professor of Chemistry1640 Chemistry
4:00 PM - 5:00 PM


Tuesday, April 11, 2017


Seminar

Onn Brandman


Prof Onn Brandman , Assistant Professor of Biochemistry, Stanford University
1640 Chem
4:00PM - 5:30PM
brandman@gmail.com


Tuesday, April 18, 2017


Seminar

Analytical Chemistry Seminar


Dr Saiful Chowdhury , Assistant Porofessor, University of Texas, Arlington
Mass spectrometry cleavable chemical strategies for protein interactions and protein modifications
CHEM 1640
4:00 PM - 5:30 PM
bruotolo@umich.edu


Wednesday, April 19, 2017


Seminar

TBA


Qiu Wang , Duke University
4:00 PM - 5:00pm


Tuesday, June 06, 2017


Bristol-Myers Squibb Symposium Symposium

TBA


John Hartwig , UC-Berkeley
2:00pm - 5:30pm


Thursday, February 15, 2018


GOMBERG Seminar

Phil Bevilacqua


4:00 PM - 5:30 PM
pcb5@psu.edu